The recent advances in stem cell research were listed as one of the most significant health-related stories in the past 25 years by CNN, second only to the complete mapping of the human genome.
The ability to use human stem cells in treating diseases has provided amazing breakthroughs for medical science. Though the science and the issue of the debate over stem cell research can be confusing, the facts are clear.
Stem cells function to replenish dead or lost cells in areas of the body, as needed. Stem Cells can be thought of as “master cells.” This is why stem cells redefine the meaning of health and youthfulness.
Seldom does a new supplement with all natural ingredients come along that changes the way we think about our health and the aging process. That time has arrived as the benefits of stem cell research enters our life. Finally, we can experience the wide ranging effects of enhanced adult stem cells simply by taking a few capsules over a period of time. The ingredients in the capsules help to support the release of stem cells from the bone marrow into the bloodstream. Through a natural process, those stem cells then travel to areas of the body where they are most needed.
We invite you to join us on a journey of new hope and discovery as our body responds to the elevated adult stem cells. And the journey can be as exciting as the final results.
The stem cell revolution enters our lives. Finally.
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Why do we need stem cells?
Stem cells function to replenish dead or lost cells in areas of the body, as needed. This could occur in the organ where the stem cell resides or in other organs. For example, bone marrow stem cells (also referred to as hematopoietic stem cells) would be able to replenish lost blood and provide new immune cells during infection. At the same time, these stem cells have the capacity to detect damaged organs and migrate to repair the injured tissues. Another example is neural stem cells (brain). It is suspected that they may play a role in brain repair following injury and also in the replacement of dying neurons (brain cells). These subjects are the focus of active research in labs around the world. References: Rosenthal N, N Engl J Med 2003;349:267; Nat Med 2002;8:647; Stewart et al, Blood 2001;98:1246; Burt et al, Blood 2002;99:768; Myers LA et al., Blood 2002;99:872
What is the Difference between Adult and Embryonic Stem Cells?
All stem cells are termed pluripotent, meaning one stem cell could form multiples types of cells. Both adult and embryonic stem cells are taken from living human tissue. Adult stem cells are readily available in many different areas of the human body and do not harm the individual from whom they are taken. Embryonic stem cells, however, are harvested from living embryos and the developing human life must be killed in order to extract the stem cells.
Embryonic stem cell research seems to get all the press at the expense of adult stem cell research, even though stem cells taken from embryos have yet to help a single patient. In fact, in clinical trials, stem cells taken from embryos often grow tumors and have shown great genetic instability.
The US National Institute of Health (NIH)’s own website on stem cells states: "Adult stem cells…are currently the only type of stem cell commonly used to treat human diseases…The clinical potential of adult stem cells has also been demonstrated in the treatment of other human diseases that include diabetes and advanced kidney cancer."(National Institutes of Heath, "Stem Cell Information: Frequently Asked Questions"
Embryonic stem cells have NOT treated one human patient
In fact, after over 25 years of experiments using embryonic stem cells in animal models, researchers have yet to develop a successful treatment in mice for any disease that could be used as a model to undertake the first steps for a clinical trial with human patients. Nor will treatments with Embryonic Stem Cells happen anytime soon. According to a L.A. Times report (12/6/06) , the California Institute of Regenerative, flush with $3 billion in state money over the next 10 years, in its draft plan now admits that it is "unlikely that [it] will be able to fully develop stem cell therapy for routine clinical use during the 10 years of the plan." At best, the Institute says it hopes to establish, in principal, an embryonic stem cell treatment for at least one disease.
It is important to note then when President Clinton’s National Bioethics Advisory Commission, in 1999, first proposed federal funding of embryonic stem cell research it laid down as a condition that "the derivation of stem cells from embryos remaining following infertility treatments is justifiable only if no less morally problematic alternatives are available for advancing the research." At the time the Commission concluded such alternatives were not available, but noted this conclusion "is a matter that must be revisited continually as science advances." (Ethical Issues in Human Stem Cell Research, National Bioethics Advisory Commission, Sept., 1999 )
Advocates of Embryonic Stem Cell Research (ESCR) have shown a noticeable indifference to assessing the scientific advances for less morally problematic alternatives to embryonic stem cell research over the last 8 years. They simply assert the supposed superiority of Embryonic Stem Cells to cure almost anything and dismiss peer-reviewed evidence showing the benefits of adult and cord blood stem cells, both in animal models and in real human patients.
Claims unsubstantiated for embryonic stem cells
Current or potential embryonic stem cell problems:
Difficult to establish and maintain
Difficulty in obtaining pure cultures in the dish
Potential for tumor formation and tissue destruction
*Wakitani S et al.; “Embryonic stem cells injected into the mouse knee joint form teratomas and subsequently destroy the joint”; Rheumatology 42, 162-165; January 2003
Questions regarding functional differentiation
*Hansson M et al., “Artifactual insulin release from differentiated embryonic stem cells”, Diabetes 53, 2603-2609, October 2004 *Sipione S et al., “Insulin expressing cells from differentiated embryonic stem cells are not beta cells”, Diabetologia 47, 499-508, 2004 (published online 14 Feb 2004) *Rajagopal J et al.; “Insulin staining of ES cell progeny from insulin uptake”; Science 299, 363; 17 Jan 2003 *Zhang YM et al.; “Stem cell-derived cardiomyocytes demonstrate arrhythmic potential”; Circulation 106, 1294-1299; 3 September 2002
Problem of immune rejection
Genomic instability
*Cowan CA et al., “Derivation of embryonic stem-cell lines from human blastocysts”, New England Journal of Medicine 350, 13; published online 3 March 2004 *Draper JS et al., “Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells”, Nature Biotechnology 22, 53-54; January 2004 *Humpherys S et al.; “Epigenetic instability in ES cells and cloned mice”; Science 293, 95-97; 6 July 2001
Few and modest successes in animals, no clinical treatments
Ethically contentious
73 diseases and conditions benefit from adult stem cells
Benefits of Stem Cells to Human Patients Adult Stem Cells v. Embryonic Stem Cells
The Facts - Prentice, D. "Adult Stem Cells" Appendix K in Monitoring Stem Cell Research: A Report of the President's Council on Bioethics (Washington, DC: Government Printing Office, 2004), 309-346.
Do embryonic stem cells produce a fountain of youth, or an eruption of cancer?
Political:
”If scientists are correct, stem cell research could result in a veritable fountain of youth by replacing diseased or damaged cells.” – Senator Arlen Specter of Pennsylvania, Congressional Record, March 16, 2005, p. S2764
Science:
”The emerging truth in the lab is that pluripotent stem cells are hard to rein in. The potential that they would explode into a cancerous mass after a stem cell transplant might turn out to be the Pandora’s box of stem cell research” – Ethicist Glenn McGee of the University of Pennsylvania, quoted in E. Jonietz, “Innovation: Sourcing Stem Cells,” Technology Review, January/February 2001, p. 32
It is Dr. McGee’s concern that is being borne out by science. Tulane University research professor Brian Butler says: “We’re not against stem-cell research of any kind. But we think there are advantages to using adult stem cells. For example, with embryonic stem cells, a significant number become cancer cells, so the cure could be worse than the disease.” See Heather Heilman, “Great Transformations,” The Tulanian, Spring 2004
The fountain of youth seems less appealing when it might become a cancerous eruption of many cell types at once in a patient’s body. The political hype about embryonic stem cells is ignoring real dangers to patients.
#2: Spinal cord injury? - Pay attention to your own scientists’ results
Christopher Reeve may have failed to review the scientist’s finding his foundation supported.
Political: ”If we do the work that we can do in this country, the work that we will do when John Kerry is president, people like Christopher Reeve are going to walk, get up out of that wheelchair and walk again.” – Senator John Edwards, vice-president candidate, on embryonic stem cells, October 11, 2004.
Science: ”Pluripotent stem cells have been detected in multiple tissues in the adult, participating in normal replacement and repair, while undergoing selfrenewal.” – Firstsentence of a scientific study funded by the Christopher Reeve Paralysis Foundation, submitted for publication March 31, 2000. The authors cite 11 earlier studies in support of this statement, and cocnclude that mesenchymal stem cells from adult bone marrow would have significant advantages over embryonic stem cells in treating a variety of neurological diseases. See D. Woodbury et al., “Adult Rat and Human Bone Marrow Stromal Cells Differentiate Into Neurons,” 61 J. of Neuroscience Research 364-70 (2000)
Adult stem cells from patients’ own nasal cavity have already been used in Portugal to benefit dozens of chronic spinal cord injury patients, including several Americans who began to walk with braces after years of chronic paralysis. They have told their story in a US congressional testimony.
#3: Diabetes treatments: adult stem cells vs. embryonic stem cells
Political: “Stem cell research offers the greatest potential for curing … diabetes.” – Rep. Mark Kirk (R-IL) at a rally for embryonic stem cell research, UPI, May 16, 2005.
Science: ”Is the use of embryonic stem cells close to being used to provide a supply of islet cells for transplantation into humans?” ”No. The field of embryonic stem cells faces enormous hurdles to overcome before these cells can be used in humans. The two key challenges to overcome are making the stem cells differentiate into specific viable cells consistently, and controlling against unchecked cell division once transplanted. Solid data of stable, functioning islet cells from embryonic stem cells in animals has not been seen.” – Autoimmune Disease Research Foundation, “Q & A,” (accessed May 16, 2005)
The first successful islet cell transplant from a living donor was announced (The Lancet, publishe online April 19, 2005).
A new approach using adult spleen cells, pioneered by Harvard researchers, has achieved permanent reversal of diabetes in hundreds of animals and have been approved by the FDA for human trials (The New York Times, November 9, 2004).
”Humans are a richer source of insulin-making stem cells than fertilized eggs. … 7 percent of human embryonic stem cells are capable of making insulin, compared to 70 percent of stem cells from adult human blood and umbilical cord blood.” - Dr. Yong Zhao, University of Illinois, presented his study at the annual American Diabetes Association. Reported by CNNMoney.com June 25, 2007.
#4: Science vs. politicians
Political: “Well, let me make it very clear about adult stem cells or cord blood. There’s not a researcher of any renown out there whatsoever, who believes that they can do anything more than help with blood related diseases. As a matter of fact 14 of the 15 diseases that people most die from in the United States of America can never be addressed by adult stem cells.” – Representative Michael Castle (R-DE), CNN Newsnight, 5/24/05 ”There are also cord blood stem cells. But the real opportunity for medical advance lies in the flexible embryonic stem cells…” – Senator Arlen Specter, Cong. Record, October 21, 2005, p. S11729
Science: Adult stem cells “are currently the only type of stem cells commonly used to treat human diseases… The clinical potential of adult stem cells has also been demonstrated in the treatment of other human diseases that include diabetes and advanced kidney cancer.” – National Institute of Health, “Stem Cell Information: The official National Institutes of Health resource for stem cell research,” Frequently Asked Questions
”All actively developing human embryonic stem cell lines may spontaneously accumulate genetic abnormalities associated with cancer.” – J. Draper et al., “Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells.”
There has not been a single disease in humans benefiting from embryonic stem cells. Yet, there are at least 73 human diseases that benefited from adult stem cells (taken from Peer-Reviewed studies).
StemExperts.com Inc. Toronto, Canada • Detroit, US • Amsterdam, EU
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Seek the advice of a competent health care professional for your specific health concerns. The above statements are anecdotal and may not represent typical results. Individual results will vary.
The recent advances in stem cell research were listed as one of the most significant health-related stories in the past 25 years by CNN, second only to the complete mapping of the human genome.
